Lab Overview

The goal of our research is to quantitatively understand human RNA regulatory networks and their dysregulation in human disease. RNA metabolism is a function of multiple interdependent regulatory processes orchestrated by ribonucleoprotein complexes (RNPs). RNPs are dynamic regulatory interactions between RNA-binding proteins (RBPs) and RNAs that determine the fate of an RNA. Systematic analysis of RNA regulation with methods that quantitatively measure each step in RNA metabolism is necessary to understand pathophysiological changes in gene regulatory networks. We employ quantitative, transcriptome-wide techniques to map physical interactions as well as RNA regulatory events. We combine experimental and computational approaches to investigate normal and aberrant RNA regulation in the context of human steroidogenesis and cancer.

Our lab is in the Department of Biochemistry and Molecular Genetics. We are members of the vibrant and interactive RNA Bioscience Initiative

News

Latest lab news!

Team

 

Learn about the eclectic folks (postdocs, grad students, undergrads, and techs) in the lab.

Projects

 

We have projects investigating the molecular mechanisms of RBPs and lncRNAs in both human steroidogenesis and cancer.

Publications

Check out our papers, reviews, and book chapters from the lab.